non-nucleoside polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T28762	Setrobuvir	RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease , SARS-CoV , DNA/RNA Synthesis
	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding aff...		HCV Protease , SARS-CoV , DNA/RNA Synthesis
T21537L	TMC647055 Choline Hydroxide Salt	TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease
	TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with mi...		HCV Protease
T31369	Deleobuvir	BI207127,BI-207127,BI 207127,BI-207127NA
	Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
T15631	JTK-853		Others
	JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, re...		Others
T38510	ABT-072 potassium trihydrate
	ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) ...
T62160	AS-136A
	AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium is a non-nucleoside hepatitis C virus (HCV) polymerase inhibitor. sodium exhibits inhibition of the RNA-dependent RNA polymerase (RNA polymerase) encoded by the HCV NS5B gene. sodium inhibits D...
T35533	6-Hydroxypyridin-3-ylboronic Acid
	6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B)...
T74516	CI-39
	CI-39, a natural antiviral product, serves as a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting wild type HIV-1. It exhibits an effective concentration (EC50) of 3.40 µM against the virus, while its cyto...
T70846	Deleobuvir sodium
	Deleobuvir sodium is the salt form of Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with...
T69657	GS-441524 HCl
	GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infecti...
T73814	Cis-Lomibuvir
	Cis-Lomibuvir (cis-VX-222), a cis-isomer of Lomibuvir, is a selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase (RdRp), targeting thumb pocket 2 with a dissociation constant (Kd) of 17 nM. I...